Cancer is often referred to in some of Edd Gould's videos.
Cancer is represented as a crudely drawn green dinosaur with a thick, v-shaped unibrow and two black dots for eyes.
In Edd vs Cancer, Cancer is carrying a microphone, before being punched in the face by a crudely drawn Edd.
In Edd vs Cancer, Thomas Ridgewell animated Edd beating up Cancer, who used a fist, and the screen suddenly fills with fire. Cancer itself, however, didn't disappear, signifying that Edd was still battling it.
In Eddsworld: Legacy, Thomas Ridgewell summarises Edd's life to those who didn't know about it, including how he had developed leukaemia in 2006, Edd's fight against Cancer, ultimately beating it into remission, the sudden return of it and how it ultimately led to his death in 2012.